Thyrotropin-releasing hormone

Thyrotropin-releasing hormone (TRH) is a tripeptide hormone that stimulates the release of TSH and prolactin by the anterior pituitary. TRH is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system .

The sequence of TRH was first determined and the hormone was synthesized by Roger Guillemin and Andrew V. Schally in 1969.

The presence of TRH can also be detected in other parts of the brain, such as the gastrointestinal system and pancreatic islets. Medical preparations of TRH are used in diagnostic tests of thyroid disorders and in acromegaly.

Structure : (pyro)Glu-His-Pro-NH₂
Molecular weight : 359.5 D